Recent Evidence Shows That Signals from the Extracellular Matrix (ECM)can

Recent evidence shows that signals from the extracellular matrix (ECM) can regulate the expression of genes in the cell nucleus. A likely mechanism is that

A) mechanical signals of the ECM can alter the cytoskeleton, which can alter intracellular signalling.
B) intracellular signals might cause changes in the fibronectin binding to the cell surface.
C) orientation of microtubules to the ECM can change gene activity.
D) integrins that receive signals from the ECM migrate to the nucleus.
E) proteoglycans in the ECM undergo endocytosis and produce intracellular signalling molecules.