Genomic imprinting is generally due to the addition of methyl (-CH₃)groups to C nucleotides in order to silence a given gene. If this depends on the sex of the parent who transmits the gene, which of the following must be true?
A) Methylation of C is permanent in a gene.
B) Genes required for early development stages must not be imprinted.
C) Methylation of this kind must occur more in males than in females.
D) Methylation must be reversible in ovarian and testicular cells.
E) The imprints are transmitted only to gamete-producing cells.

Question

Quizplus · Accepted Answer

Methylation must be reversible in ovarian and testicular cells to allow for the parent-of-origin specific imprinting patterns to be established in the offspring. This reversibility ensures that each generation can establish its own imprinting marks according to the sex of the transmitting parent.

Genomic Imprinting Is Generally Due to the Addition of Methyl