The TATA sequence is found approximately 25 nucleotides upstream from the start site of transcription. This most probably relates to which of the following?
A)its involvement with binding the transcription factor that helps place polymerase II in the correct location
B)its direct binding of polymerase II
C)the ability of this sequence to bind to the start site
D)the supercoiling of the DNA near the start site
E)the 3-D shape of a DNA molecule

Question

Quizplus · Accepted Answer

The TATA sequence is recognized by a transcription factor known as TFIID, which is required for the placement of RNA polymerase II in the correct location to initiate transcription. The TATA sequence is not known to directly bind polymerase II, nor is it involved in binding to the start site or supercoiling of DNA. The 3-D shape of a DNA molecule may affect transcription, but this is not directly related to the presence of the TATA sequence. Therefore, choice A is the most likely explanation.

The TATA Sequence Is Found Approximately 25 Nucleotides Upstream from the Start