Unequal crossing over during prophase I can result in one sister chromosome with a deletion and another with a duplication. A mutated form of hemoglobin, known as hemoglobin Lepore, is known in the human population. Hemoglobin Lepore has a deleted set of amino acids. If it were caused by unequal crossing over, what would be an expected consequence?
A)If it is still maintained in the human population, hemoglobin Lepore must be selected for in evolution.
B)There should also be persons born with, if not living long lives with, an anti-Lepore mutation or duplication.
C)Each of the genes in the hemoglobin gene family must show the same deletion.
D)The deleted gene must have undergone exon shuffling.
E)The deleted region must be located in a different area of the individual's genome.

Question

Quizplus · Accepted Answer

If hemoglobin Lepore is caused by unequal crossing over resulting in a deletion, then there may also be individuals born with a duplication of the same region. These individuals may have a different form of mutated hemoglobin, referred to as anti-Lepore.

Unequal Crossing Over During Prophase I Can Result in One