Many mammals have skins and mucous membranes that are sensitive to phenolic secretions of plants like poison oak (Rhus). These secondary compounds are primarily adaptations that

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The presence of phenolic secretions in plants like poison oak is primarily an adaptation to inhibit herbivory. Mammals that come into contact with these secretions often experience an allergic reaction that is thought to deter them from eating the plant. This is a common strategy employed by many plants to discourage herbivores from consuming their tissues.

Many Mammals Have Skins and Mucous Membranes That Are Sensitive