Which signs and symptoms are associated with Werdnig-Hoffmann disease?

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Werdnig-Hoffmann disease (spinal muscular atrophy type 1)is the most common paralytic form of floppy infant syndrome (congenital hypotonia).It is characterized by progressive weakness and wasting of skeletal muscle caused by degeneration of anterior horn cells.Kugelberg-Welander syndrome is a juvenile spinal muscular atrophy with a later onset.Charcot-Marie-Tooth disease is a form of progressive neural atrophy of muscles supplied by the peroneal nerves.Progressive weakness of the distal muscles of the arms and feet is found.Duchenne's muscular dystrophy is characterized by muscles,especially in the calves,thighs,and upper arms that become enlarged from fatty infiltration and feel unusually firm or woody on palpation.The term pseudohypertrophy is derived from this muscular enlargement.

Which Signs and Symptoms Are Associated with Werdnig-Hoffmann Disease