The most major impediment to relations with Native Americans during the settlement of the British Colonies was

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Disease was the most major impediment to relations with Native Americans during the settlement of the British Colonies. Europeans brought various diseases with them that Native Americans had no immunity to, leading to significant population declines and devastating consequences for indigenous communities. This factor, more than any other, affected the early relationship between Europeans and Native Americans.

The Most Major Impediment to Relations with Native Americans During