In nonsteroid hormones,the hormone itself is the first messenger.

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In nonsteroid hormones, the hormone itself acts as the first messenger by binding to a receptor on the cell surface and triggering a signaling cascade within the cell. This can lead to the production of a second messenger, which then communicates the signal to the appropriate target within the cell. Steroid hormones, on the other hand, can pass through the cell membrane and directly interact with intracellular receptors, acting as both first and second messengers.

In Nonsteroid Hormones,the Hormone Itself Is the First Messenger