The second stage of B cell development usually takes place in the lymph nodes and spleen.

Name: The second stage of B cell development usually takes place in the lymph nodes and spleen.
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During the second stage of B cell development, mature B cells migrate to secondary lymphoid organs such as lymph nodes and spleen, where they encounter antigens and undergo activation and differentiation into plasma cells or memory B cells.

The Second Stage of B Cell Development Usually Takes Place