The chloride shift makes it possible for carbon dioxide to be buffered in the red blood cell and then carried as bicarbonate in the plasma.

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The chloride shift refers to the movement of chloride ions into the red blood cell as a way to balance the charge when bicarbonate is formed from carbon dioxide. This allows for efficient transport of carbon dioxide in the blood from tissues to the lungs, where it can be released.

The Chloride Shift Makes It Possible for Carbon Dioxide to Be