Familial hypercholesterolemia, an autosomal dominant disease, is five times more frequent in the Afrikaner population of South Africa than in the original population of Europe from which the ancestors to the Afrikaners immigrated.This represents an example of:

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Quizplus · Accepted Answer

The increased frequency of familial hypercholesterolemia in the Afrikaner population is an example of the founder effect, which occurs when a small group of individuals establishes a new population with a limited genetic diversity. The original European population had a lower frequency of the disease, but the Afrikaner population descended from a small group of individuals who brought a high frequency of the disease-causing allele to South Africa, resulting in a higher frequency of the disease in the Afrikaner population. Natural selection and kin selection are not relevant to this example, and there is no evidence of a bottleneck event.

Familial Hypercholesterolemia, an Autosomal Dominant Disease, Is Five Times More