According to John Relethford, the most likely reasons for modern humans to have migrated out of Africa during the late Pleistocene include:

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The most likely reasons for modern humans to have migrated out of Africa during the late Pleistocene include both loss of food supply and climate change. As the climate became drier and the environment became less conducive to human survival, modern humans had to look for new areas to settle and search for resources. This, combined with the depletion of resources in their current locations, led to the eventual migration out of Africa. Disease is not considered to be a significant factor in the initial migration out of Africa.

According to John Relethford, the Most Likely Reasons for Modern