Before 1960, reports surfaced that soy formula-fed infants were developing hypothyroidism.The addition of what supplement to these formulas ameliorated this problem?

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Soybean, an important source of protein in many developing countries, has goitrogenic properties when iodine intake is limited.The isoflavones, genistein and daidzein, inhibit the activity of TPO and can lower thyroid hormone synthesis.Furthermore, soybean interrupts the enterohepatic cycle of thyroid hormone metabolism.Since the addition of iodine to soy-based formulas in the 1960s, there have been no further reports of hypothyroidism developing in soy formula-fed infants.

Before 1960, Reports Surfaced That Soy Formula-Fed Infants Were Developing