How may phenobarbital, used for anticonvulsant therapy, interfere with the intestinal absorption of calcium?

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Quizplus · Accepted Answer

Phenytoin, phenobarbital, and primidone increase the metabolism of vitamin D in the liver.The result is that dietary calcium absorption is impaired.Long-term use of these medications places children at risk for rickets and adults at risk for osteomalacia.To prevent this, vitamin D supplementation is recommended.

How May Phenobarbital, Used for Anticonvulsant Therapy, Interfere with the Intestinal