An Appropriate Technique for a Nurse to Implement When Administering

An appropriate technique for a nurse to implement when administering a topical medication with a systemic effect is:

A) Using clean gloves for application to open skin areas
B) Applying thick layers of creams and ointments
C) Massaging nitroglycerin products into the skin
D) Rotating sites, avoiding reuse of a site for at least 1 week