The Transition of Opiate Use from an Acceptable,if Often Abused

The transition of opiate use from an acceptable,if often abused pain reliever to that of a pleasure-seeking drug also saw a change _________.

A) in the drug's pharmacology,which provided more relief for the "psychological pain" of poverty and urban life
B) in the distribution from doctors to pushers
C) in the demographics of the user to that of working-class-and very often black-males
D) its former female demographic,which turned increasingly to social drinking during the Roaring Twenties