In the general activation syndrome (GAS), described by Selye, the sympathetic division of the autonomic nervous system first becomes activated during:

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According to Selye's GAS model, during the alarm reaction, the sympathetic division of the autonomic nervous system becomes activated as part of the immediate stress response. This is characterized by the release of stress hormones such as adrenaline, increased heart rate and blood pressure, and other physiological changes associated with the fight or flight response.

In the General Activation Syndrome (GAS), Described by Selye, the Sympathetic