In the general activation syndrome (GAS), described by Selye, energy reserves become so taxed and depleted that the body starts to give up during:

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The stage of exhaustion is the final stage of GAS, where energy reserves become so depleted that the body can no longer maintain its resistance to the stressor. This can lead to physical and mental fatigue, illness, and even death.

In the General Activation Syndrome (GAS), Described by Selye, Energy