In the case of McCulloch v.Maryland,the main issue was whether or not Congress had the power to:

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The main issue in McCulloch v. Maryland was whether or not Congress had the power to charter a bank. The State of Maryland had attempted to tax the Second Bank of the United States, but the Supreme Court ultimately ruled that such a tax was unconstitutional because it interfered with federal authority. Therefore, the correct choice is A, "charter a bank."

In the Case of McCulloch V