Because stratospheric ozone occurs at 10 to 50 kilometers elevation (6 to 31 miles above Earth's surface), it is not vulnerable to human influence.

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Despite occurring at high altitudes, stratospheric ozone is vulnerable to human influence due to the release of ozone-depleting substances such as chlorofluorocarbons (CFCs) and halons into the atmosphere. These substances can create chemical reactions that destroy ozone molecules, leading to the formation of the ozone hole. Actions such as the Montreal Protocol have helped to reduce the use of these substances and protect the stratospheric ozone layer.

Because Stratospheric Ozone Occurs at 10 to 50 Kilometers Elevation