The Rate of a Typical Enzyme-Catalyzed Reaction

The rate of a typical enzyme-catalyzed reaction:

A) Is independent of pH over a broad range of pH values.
B) Is approximately proportional to the substrate concentration as long as the substrate concentration is much lower than the Michaelis constant (Km) .
C) Rises by a factor of about 4 when the temperature is raised by 10° C.
D) Is no longer affected by the enzyme concentration at saturating substrate concentrations.
E) Is virtually independent of the temperature, as long as heat denaturation is avoided.