A Patient Is Shown to Have a Deletion of 500

A patient is shown to have a deletion of 500 base pairs within the 3.7-kilobase pair sequence between the promoter of the L-type pyruvate kinase (PK) gene and an erythroid cell-specific enhancer element for the PK gene.What is the most likely outcome of the mutation in erythroid cells?

A) PK will be produced at a higher rate.
B) Transcriptional initiation becomes impossible.
C) There will be no change in the rate of enzyme synthesis.
D) There will be faulty splicing of the transcript.
E) The rate of transcription initiation by transcription factor IIH will be reduced.