Lane 1 in the Following Southern Blot Contains a Sample

Lane 1 in the following Southern blot contains a sample from a normal control, and lane 2 contains a sample from a patient.The arrow indicates the location of the wells in the agarose gel used in this analysis.The probe used was a complementary DNA (cDNA) .Which type of mutation is most likely, on the basis of these data?

A) Point mutation that changes a codon encoding glutamic acid into a stop-codon.
B) Deletion of part of one exon.
C) A single-nucleotide polymorphism that has eliminated a restriction site.
D) Duplication of three exons.
E) Deletion of the entire gene.