Loss of Heterozygosity in Genomic Locations Close to the Site

Loss of heterozygosity in genomic locations close to the site of the mutation is observed in the malignant tumors of many patients with inherited cancer susceptibility.The most likely cause for loss of heterozygosity in these patients is:

A) A missense mutation in the intact copy of the affected tumor suppressor gene.
B) A nonsense mutation in the intact copy of the affected tumor suppressor gene.
C) A frameshift mutation in the intact copy of the tumor suppressor gene.
D) Amplification of the affected oncogene.
E) Mitotic crossing over of the affected chromosome.