The effect of the chemotherapeutic drug methotrexate is best described as:
A) Disruption of the mitotic spindle.
B) Impaired synthesis of deoxyribonucleotides from ribonucleotides.
C) Inhibition of orotic acid synthesis in the biosynthetic pathway of pyrimidine nucleotides.
D) Depletion of tetrahydrofolate.
E) Induction of mutations by DNA methylation.
Correct Answer:
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