Cholecalciferol, formed by the action of sunlight on 7-dehydrocholesterol in the skin, has to be converted to the fully active calcitriol before it can induce its physiological actions.The rate-limiting step in this process is catalyzed by an enzyme in:

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This is the reason why signs of vitamin D deficiency are common in patients with kidney failure but not in patients with liver cirrhosis.

Cholecalciferol, Formed by the Action of Sunlight on 7-Dehydrocholesterol in the Skin