Which of the following H₂ receptor antagonists can cause the development of gynecomastia in men and inhibit several cytochrome P450 metabolic enzymes and is responsible for increasing the elimination of more than 25 different drugs?

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Other less common adverse effects include skin rash,agitation,depression,hepatitis,decreased libido,and gynecomastia (high-dose cimetidine).Males who develop gynecomastia have symptoms of breast swelling and tenderness.Cimetidine inhibits several cytochrome P450 metabolic enzymes and is responsible for increasing the elimination of more than 25 different drugs.

Which of the Following H₂ Receptor Antagonists Can Cause the Development