During the last trimester of pregnancy,drug transfer to the fetus is more likely to occur.Which of the following explanations provides a reason for this possibility?

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Drug transfer to the fetus is more likely during the last trimester,as a result of enhanced placental blood flow,increased surface area,thinner membranes separating the maternal blood and fetus,and an increased amount of free drug in the mother's circulation.
Increased fetal surface area,not decreased,is a factor that affects drug transfer to the fetus.The placenta's surface area does not increase during this time.Drug transfer is increased due an increased amount of free drug,not protein-bound drug,in the mother's circulation.Fetal size is incorrect because the first trimester of pregnancy is the period of greatest danger of drug-induced developmental defects.During this period the fetus undergoes rapid cell proliferation.Gestational age is more important than fetal size.

During the Last Trimester of Pregnancy,drug Transfer to the Fetus