The depressed or "flat" feeling that drug users may feel when they are not taking a drug is related to

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When drugs are taken, they can often flood the brain with neurotransmitters like dopamine, which can lead to a "high" or pleasurable feeling. However, over time, drug use can lead to a reduction in the production of these natural chemical regulators. This can cause users to feel depressed or flat when they are not taking the drug, since their brains are no longer able to produce the same levels of feel-good chemicals. This reduction in natural chemical regulators is a key factor in the withdrawal symptoms experienced by drug users.

The Depressed or "Flat" Feeling That Drug Users May Feel