A patient has been taking warfarin (Coumadin), which is highly protein-bound. The patient will begin taking gemfibrozil, which is also highly protein-bound. The nurse will observe the patient closely for:

Question

Quizplus · Accepted Answer

When two highly protein-bound drugs are taken together, the competition for protein binding sites can cause an increase in the free concentration of the drugs, leading to an increased effect. Therefore, the nurse should observe the patient closely for an increased effect of warfarin.

A Patient Has Been Taking Warfarin (Coumadin), Which Is Highly