A patient who is HIV-infected takes 800 mg of indinavir (Crixivan), a protease inhibitor medication. The provider has ordered adding ritonavir (Norvir) to the regimen. The nurse will teach the patient that the addition of ritonavir:

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The addition of ritonavir to indinavir allows for decreasing the dosing frequency from three times daily to twice daily. This is because ritonavir enhances the pharmacokinetics of indinavir, increasing its effectiveness and allowing for less frequent dosing. However, ritonavir can also lead to potential side effects such as increased cholesterol and triglycerides, worsened insulin resistance, and increased dietary restrictions.

A Patient Who Is HIV-Infected Takes 800 Mg of Indinavir