Which of the following is a mechanism of apoptosis in hematopoiesis?
A) Expansion of B cell clonal populations in response to infection
B) Elimination of PMNs and eosinophils after an inflammatory response
C) Production of RBCs in response to anemia
D) Progression of acute leukemias

Question

Quizplus · Accepted Answer

Hematopoiesis involves the production and differentiation of multiple types of blood cells. Apoptosis is an important mechanism to regulate the number of cells in circulation and maintain homeostasis. In particular, apoptosis plays a role in eliminating PMNs and eosinophils after an inflammatory response to prevent excessive inflammation and tissue damage. Expansion of B cell clonal populations in response to infection is a process known as clonal expansion and does not involve apoptosis. Production of RBCs in response to anemia is regulated by erythropoietin and does not involve apoptosis. Progression of acute leukemias is a pathological process that involves the accumulation and expansion of abnormal cells and is not a normal mechanism of hematopoiesis.

Which of the Following Is a Mechanism of Apoptosis in Hematopoiesis