When mutations occur in the globin chains of hemoglobin, what two interactions can be impaired?
A) Stability and hemoglobin-oxygen affinity
B) Iron binding and stability
C) Heme synthesis and affinity
D) Iron regulation and affinity

Question

Quizplus · Accepted Answer

Mutations in the globin chains of hemoglobin can impair two interactions: stability and hemoglobin-oxygen affinity. Stability is essential for the proper folding and function of hemoglobin, while hemoglobin-oxygen affinity determines the capacity of hemoglobin to bind with oxygen. Mutations in the globin chains can disrupt these interactions, leading to the development of various hemoglobinopathies, such as sickle cell anemia and thalassemia. Iron binding and heme synthesis do not directly involve globin chains, and iron regulation is not a direct interaction of hemoglobin.

When Mutations Occur in the Globin Chains of Hemoglobin, What