Impaired alpha chain production in alpha thalassemias causes:

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Impaired alpha chain production in alpha thalassemias leads to the formation of abnormal hemoglobins, such as Hb Bart's (gamma4) and Hb H (beta4). Overproduction of hemoglobin F and A₂ occurs in beta thalassemia, which is caused by impaired beta globin chain production. Fusion of alpha and gamma chains can occur in some types of hemoglobinopathies, but it is not specifically associated with alpha thalassemias. Normal hemoglobin distribution would not occur in alpha thalassemias due to the imbalance in globin chain production.

Impaired Alpha Chain Production in Alpha Thalassemias Causes