Impaired beta chain production translates to what on hemoglobin electrophoresis?

Question

Quizplus · Accepted Answer

Impaired beta chain production leads to an excess of alpha chains that will form tetramers, resulting in increased levels of Hb F and Hb A₂. This can be seen on hemoglobin electrophoresis as increased peaks for these hemoglobin types. There would not be an increase in Hb H or Hb A1, as these are not affected by impaired beta chain production. Hb S would also not be affected by impaired beta chain production, as it is caused by a specific mutation in the beta chain gene.

Impaired Beta Chain Production Translates to What on Hemoglobin Electrophoresis