Predict the levels of MMA and homocysteine in patients with Vitamin B₁₂ deficiency.
A)Both will be normal.
B)Both will be decreased.
C)Both will be increased.
D)MMA will be increased and homocysteine will be normal.

Question

Quizplus · Accepted Answer

In Vitamin B₁₂ deficiency, both methylmalonic acid (MMA) and homocysteine levels are typically increased. Vitamin B₁₂ is a cofactor for the conversion of methylmalonyl-CoA to succinyl-CoA, and its deficiency leads to increased MMA. It is also involved in the conversion of homocysteine to methionine, so deficiency results in elevated homocysteine levels.

Predict the Levels of MMA and Homocysteine in Patients with Vitamin