The majority of PA patients have antibodies against what component necessary for vitamin B₁₂ absorption?
A)Parietal cells
B)Vitamin B₁₂
C)Intrinsic factor
D)Blocking antibody

Question

Quizplus · Accepted Answer

Intrinsic factor is a protein secreted by the parietal cells of the stomach that is necessary for the absorption of vitamin B₁₂ in the small intestine. In PA, the immune system produces antibodies that attack and destroy the parietal cells and/or intrinsic factor, leading to vitamin B₁₂ deficiency. The majority of PA patients have antibodies against intrinsic factor. Therefore, the correct option is C, intrinsic factor.

The Majority of PA Patients Have Antibodies Against What Component