In hereditary spherocytosis, the erythrocytes become trapped in the splenic cords and run out of ATP to pump out excessive ions. What is the ion involved?

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In hereditary spherocytosis, the erythrocytes have a defect in their membrane that leads to a loss of membrane surface area and a spherical shape. This shape makes them less flexible and more prone to getting trapped in the spleen. The trapped cells run out of ATP, which is necessary for the Na+/K+ pump to function properly. Without ATP, the cells cannot pump out Na+ (sodium ions), leading to water influx, cell swelling, and eventually hemolysis.

In Hereditary Spherocytosis, the Erythrocytes Become Trapped in the Splenic