Interpret the following results: WBC count: 102 × 10⁹/L
Differential:
13% segmented neutrophils
28% band neutrophils
15% metamyelocytes
8% myelocytes
6% promyelocytes
15% lymphocytes
8% basophils
7% monocytes
LAP score: 15 (reference interval: 0-400)
What disease is associated with this WBC differential and LAP score?

Question

Quizplus · Accepted Answer

The WBC count of 102 x 10⁹/L and the presence of immature neutrophils (band, metamyelocytes, myelocytes, and promyelocytes) suggest a myeloproliferative disorder such as chronic myeloid leukemia (CML) or chronic neutrophilic leukemia (CNL). The LAP score of 15 supports the diagnosis of CML as it is typically low in CNL but can be elevated in CML. A leukemoid reaction can also mimic the differential seen in CML, but it is typically a reactive process in response to an infection or other stimulus and would not have the consistent presence of immature neutrophils seen in this case. Therefore, the best choice is B, CML.

Interpret the Following Results: WBC Count: 102 × 10⁹/L