A patient presents with a moderate leukoerythroblastic anemia, striking anisocytosis, and poikilocytosis. The anemia is normocytic, normochromic. Large platelets are noted. Dacryocytes, elliptocytes, and ovalocytes are present. Basophilic stippling is present. What disease is associated with these findings?

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The presence of a moderate leukoerythroblastic anemia along with striking anisocytosis and poikilocytosis suggests bone marrow infiltration or fibrosis which is a common feature of primary myelofibrosis (PMF). The normocytic, normochromic anemia with large platelets and the presence of dacryocytes, elliptocytes, and ovalocytes are also commonly observed in PMF. Basophilic stippling can also be seen in PMF as a result of ineffective erythropoiesis.  CML, PV, and ET are not typically associated with bone marrow fibrosis or dacryocytes and elliptocytes.

A Patient Presents with a Moderate Leukoerythroblastic Anemia, Striking Anisocytosis