A patient's CBC revealed marked leukocytosis with an increased number of immature granulocytes. A few promyelocytes and blasts were seen. There were also an increased number of eosinophils and basophils with rare immature forms. The hemoglobin and hematocrit were normal, but platelets were slightly decreased. Which disorder is associated with these findings?

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Quizplus · Accepted Answer

The marked leukocytosis with increased numbers of immature granulocytes, promyelocytes, and blasts, as well as the slight decrease in platelets, are all characteristic of chronic myeloid leukemia (CML). Eosinophilia and basophilia are also common findings in CML. A leukemoid reaction is a reactive increase in white blood cells, but the presence of blasts would indicate a neoplastic process. PMF (primary myelofibrosis) may have leukocytosis and decreased platelets, but eosinophilia and basophilia are not typical. Severe infection would not typically result in the presence of blasts.

A Patient's CBC Revealed Marked Leukocytosis with an Increased Number