Which is found in 90% of cases of PV and promotes EPO receptor activation?

Question

Which is found in >90% of cases of PV and promotes EPO receptor activation?

Quizplus · Accepted Answer

JAK2(V617F) mutation is found in over 90% of cases of polycythemia vera (PV) and promotes activation of the erythropoietin (EPO) receptor, leading to increased production of red blood cells. Bcl-x1 is not directly associated with PV, BCR/ABL1 is associated with chronic myeloid leukemia, and RAS mutations are seen in a variety of hematologic malignancies but are not specific to PV.

Which Is Found in >90% of Cases of PV and Promotes