Which World Health Organization (WHO)classification for MDS is best supported when the peripheral blood shows a general cytopenia,5-19% blasts with Auer rods,and

Question

Which World Health Organization (WHO)classification for MDS is best supported when the peripheral blood shows a general cytopenia,5-19% blasts with Auer rods,and <1 × 10⁹ /L monocytes?

Quizplus · Accepted Answer

The WHO classification for MDS is based on the percentage of blasts in the bone marrow, cytogenetics, and presence of dysplasia in one or more cell lineages. In this scenario, the peripheral blood showing cytopenia and 5-19% blasts with Auer rods suggest a diagnosis of MDS associated with excess blasts (RAEB-2), the correct answer is B. A peripheral blood count with less than 1 × 10⁹/L monocytes does not fulfill the criteria for RA or RCMD. MDS associated with isolated del(5q) is characterized by the presence of an isolated deletion on chromosome 5q in the bone marrow cells and is typically associated with macrocytic anemia and normal or increased platelet counts. Refractory cytopenia with multilineage dysplasia (RCMD) requires dysplasia in at least 10% of cells in two or more lineages.

Which World Health Organization (WHO)classification for MDS Is Best Supported