A 58-year-old male visits his physician for extreme fatigue. After conducting a standard investigation, the physician strongly suspects that the patient is suffering from CML. Which of the following lab results would confirm this picture?

Question

Quizplus · Accepted Answer

CML is characterized by the presence of a Philadelphia chromosome, which is formed by the reciprocal translocation of chromosomes 9 and 22. This translocation results in the formation of a BCR/ABL1 fusion gene, which can be detected by molecular analysis such as PCR. Therefore, a positive molecular analysis for BCR/ABL1 would confirm the suspicion of CML. Hypercellular bone marrow, dysmyelopoiesis, and increased WBC count can also be seen in CML, but they are not specific to the disease and can also be seen in other hematologic conditions.

A 58-Year-Old Male Visits His Physician for Extreme Fatigue