A male of 65 years of age is seen at a local hospital with symptoms of enlarged lymph nodes and possible gastrointestinal tract problems.The peripheral blood smear revealed cells resembling diffuse large B-cell lymphoma.The FISH studies demonstrated the translocation of BCL-1.What is the probable disease?

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Quizplus · Accepted Answer

The presence of enlarged lymph nodes, gastrointestinal tract problems, and cells resembling diffuse large B-cell lymphoma, along with the translocation of BCL-1, are all indicative of mantle cell lymphoma (MCL). MALT typically presents with mucosal-associated lymphoid tissue involvement, Burkitt leukemia presents with high-grade B-cell lymphoma and translocation of c-Myc, and follicular lymphoma often has t(14;18) translocation.

A Male of 65 Years of Age Is Seen at a Local