The man most responsible for passing the Compromise of 1850 was

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Stephen Douglas was the driving force behind the Compromise of 1850, which he pushed through Congress as a series of bills. His efforts were critical in bringing together the various factions and interests involved in the debate over slavery in the territories. Daniel Webster and William Seward played important roles in the debates over the compromise, but were not as instrumental in its passage as Douglas. John C. Calhoun was a leading pro-slavery voice, but died before the compromise was passed. Frederick Douglass was an abolitionist and critic of the compromise.

The Man Most Responsible for Passing the Compromise of 1850