Efforts to develop a leptin treatment for typical cases of human obesity have been
A) disappointing.
B) promising.
C) very successful.
D) successful, but in only 50% of obese people.
E) waiting for support from granting agencies and ethics boards before they can begin.

Question

Quizplus · Accepted Answer

Efforts to develop a leptin treatment for typical cases of human obesity have been disappointing. Despite the initial excitement generated by the discovery of leptin in 1994 and its demonstrated effectiveness in treating rare genetic disorders of severe obesity, subsequent studies found that most obese individuals have enough leptin circulating in their bloodstream, but the hormone does not work properly. Therefore, simply giving more leptin does not lead to weight loss or any improvements in metabolism. Researchers are still exploring different ways of targeting the leptin signaling pathway to develop more effective treatments for obesity.

Efforts to Develop a Leptin Treatment for Typical Cases of Human