In functional brain-imaging studies of Tourette patients who are suppressing their tics, abnormal activity has been consistently observed in the prefrontal cortex and

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Abnormal activity in the prefrontal cortex and caudate has been consistently observed in functional brain-imaging studies of Tourette patients who are suppressing their tics. The prefrontal cortex is involved in cognitive control, decision making, and impulse regulation, while the caudate is part of the basal ganglia, a group of nuclei that are important for movement control and are also involved in cognitive and emotional processes.

In Functional Brain-Imaging Studies of Tourette Patients Who Are Suppressing