Individuals with androgenic insensitivity syndrome do not develop normal internal female reproductive ducts because their

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Androgenic insensitivity syndrome occurs when individuals with XY chromosomes have a mutation in the androgen receptor gene, which prevents them from responding to androgens. In a typical male embryo, the testes release Müllerian-inhibiting substance, which causes the Müllerian ducts to regress and Wolffian ducts to develop into male reproductive structures. However, in individuals with androgenic insensitivity syndrome, the testes cannot respond to androgens, so they do not release Müllerian-inhibiting substance. This allows the Müllerian ducts to persist and develop into female reproductive structures, despite the presence of XY chromosomes.

Individuals with Androgenic Insensitivity Syndrome Do Not Develop Normal Internal