Support for the theory that tolerance is triggered by drug-induced changes in neural activity rather than from drug exposure per se came from the finding in one study that tolerance did NOT develop to the anticonvulsant effects of alcohol unless
A) convulsive stimulation was administered.
B) convulsive stimulation was administered after each alcohol injection.
C) convulsive stimulation was administered before each alcohol injection.
D) an anticonvulsant drug was administered before each alcohol injection.
E) alcohol was an anticonvulsant.

Question

Quizplus · Accepted Answer

Tolerance to the anticonvulsant effects of alcohol did not develop unless convulsive stimulation was administered after each alcohol injection, indicating that the neural adaptation to the drug's effects (in this case, its anticonvulsant properties) requires not just the drug exposure but also a specific context or additional stimulus (convulsive stimulation) following the drug administration. This supports the idea that tolerance is more about the brain's adaptation to the drug's effects in a given context rather than mere exposure to the drug.

Support for the Theory That Tolerance Is Triggered by Drug-Induced